Dr. M. S. Muthu

Professor
Department/School/Unit Name
Department of Pharmaceutical Engineering and Technology
Phone No(s): 9235195928
Email: msmuthu.phe@iitbhu.ac.in
Area of Interest: Pharmaceutical Nanotechnology, Theranostics, Cancer Nanomedicine

Dr. Muthu is a Professor of Pharmaceutics in the Department of Pharmaceutical Engineering and Technology, IIT(BHU). His research works mainly focused on targeted and/or theranostic delivery of anti-cancer drugs, antipsychotics, antithrombotics and antimicrobials. Dr. Muthu has received over 12 major awards. He has received BOYSCAST fellowship from the Department of Science and Technology (DST), India and received the CREST Award from the Department of Biotechnology (DBT), India.  He has received IMS-Research Publication Award for three years. Dr. Muthu has also received the VICE-CHANCELLOR’S MEDICAL RESEARCH AWARD, BHU and International Faculty Award (VIFA-2016), India. Among numerous other awards, Dr. Muthu has received BIRAC-DBT-Gandhian Young Technological Innovation (GYTI) Award in 2017. He has been elected as a member of the National Academy of Sciences, India (NASI) in 2019. Additionally, he is a Fellow of the Royal Society of Chemistry (FRSC).

EDUCATION:

  • B Pharm.(2002): S.B.College of Pharmacy, Dr.M.G.R.Medical University, Tamil Nadu.

  • M Pharm.(2004): Faculty of Pharmacy, Birla Institute of Technology & Science, Pilani.

  • Ph. D.(2009): Department of Pharmaceutics, IIT (BHU), Varanasi.

  • Post-Doc. (2 Yrs): Faculty of Engineering, National University of Singapore, Singapore

Our work is at the interface of pharmaceutical nanotechnology and theranostics. A major focus is the study and development of nanomaterials-based platforms to deliver drugs and their targeting particularly surface-modified polymers, polymer-ligand conjugate, and targeted nanoformulation.

Our lab is focused on the following key research areas.

  • Cancer Nanomedicine
  • Nanotheranostics for the brain, breast, and lung cancer
  • Theranostic nanomedicine for tuberculosis
  • Nanoparticulate drug delivery system for targeted thrombolysis
  • Developing controlled drug delivery systems that can be delivered to the targeted site.
  • Undergraduate:    
    • Industrial Pharmacy
    • Physical Pharmaceutics
    • Clinical Pharmacy
    • Dispensing Pharmacy
    • Microbiology and Biotechnology
  • Postgraduate:
    • Nanopharmaceutics
    • Industrial Pharmacy
    • Drug Regulatory Affairs
    • Advanced Pharmaceutical Analysis
  • Ph. D.
    • Research Methodology
    • Advanced Chemical and Bioanalytical Technique

          Research and Teaching Experience: 19 years

Awards/Honors:

  • Class Topper in B.Pharm. S.B. College of Pharmacy, Sivakasi, Tamilnadu.
  • M.Pharm. GATE Scholarship University Grant Commission, New Delhi.
  • Stipend Cadila Pharmaceuticals Limited, Ahmedabad, Gujarat.
  • Senior Research Fellowship Banaras Hindu University, Varanasi- University Grant Commission, New Delhi, India.
  • BOYSCAST FELLOWSHIP (2009-10) Department of Science and Technology (DST), India.
  • Academic Excellence Award (2012) Institute of Medical Sciences, Banaras Hindu University, Varanasi.
  • DBT-CREST AWARD (2012-13) Department of Biotechnology (DBT), India.
  • IMS-Research Publication Award (2013) Institute of Medical Sciences, Banaras Hindu University, Varanasi.
  • IMS-Research Publication Award (2014) Institute of Medical Sciences, Banaras Hindu University, Varanasi.
  • VICE-CHANCELLOR’S MEDICAL RESEARCH AWARD (2014) Institute of Medical Sciences, Banaras Hindu University, Varanasi.
  • International Faculty Award (VIFA-2016), Venus International Foundation, Chennai, India.
  • Best Young Scientist Award (2016) Pearl Foundation, Madurai, India.
  • BIRAC-DBT- Gandhian Young Technological Innovation (GYTI) Award - 2017.
  • Fellow of the Royal Society of Chemistry (FRSC)
  • Member of National Academy of Science, India

Recognitions:

  • Cancer Nanotechnology, Nano Drug Delivery Techniques - Workshop, Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore (TN), 27 April, 2012.
  • Nano drug formulations: better options for anti-psychotic and anti-cancer therapy, NASI-Young Scientist Platinum Jubilee Award, National Academy of Sciences, India, Allahabad (UP), 19 July, 2012.
  • Anti-psychotic Nanomedicine and Cancer Theranostics, INSA-Young Scientist Award, Indian National Science Academy, India, New Delhi, April, 2013.
  • Targeted theranostics nanomedicine: formulation, characterization and cancer application. Biomaterials in Medicinal Chemistry National Conference at Department of Natural Chemistry at Madurai Kamaraj University, Madurai, India during 14 April 2017.
  • 2nd Prize for poster presentation, M.Tech. level, Institute Day – 2017, Indian Institute of Technology (BHU), Varanasi -221005.
  • 1 st Prize for poster presentation, NIPiCON – 2018, International conference on “Innovation in Pharmaceutical Research by Interdisciplinary Approach’’ in Nirma Institute of Pharmacy, Ahmedabad, Gujarat.
  • Nanotheranostics: micelles for early diagnosis and therapy of cancer. Nanopharmaceutics and Advanced Drug Delivery held on 17th August 2018 in Dublin, Ireland.

Reviewer for Journals:

  • Biomaterials (Publisher – Elsevier, U.S.A)
  • Nanomedicine: Nanotechnology Biology and Medicine (Publisher – Elsevier, U.S.A)
  • Journal of Controlled Release (Publisher – Elsevier, U.S.A)
  • Nanoscience and Nanotechnology Letters (Publisher – American Scientific Publishers)
  • Nanomedicine (Publisher – Future Medicine, U.K)
  • Molecular Pharmaceutics (Publisher – American Chemical Society)
  • International Journal of Pharmaceutics (Publisher – Elsevier, U.S.A)
  • Expert opinion on drug delivery (Publisher – Informa healthcare, USA)
  • Journal of Pharmacy and Pharmacology (Publisher – Wiley, U.K)
  • Drug Delivery (Publisher – Informa healthcare, USA)
  • Therapeutic Delivery (Publisher – Future Science, U.K) and more….

Editor/Editorial board member for Journals:

  • Editor-in-Chief: Research and Reviews: Pharmacology and Toxicology Studies
  • ISRN Biomedical imaging (Publisher – Hindawi, U.S.A)
  • ISRN Pharmaceutics (Publisher – Hindawi, U.S.A)
  • ISRN Biomaterials (Publisher – Hindawi, U.S.A)
  • World Journal of Methodology
  • BioMed International (Pharmaceutics – Lead Guest Editor) (Publisher – Hindawi, U.S.A)

S.No.

Project title

Scheme, Funding agency and Duration

Amount

P.I. or Co.P.I.

Status

1.

Studies on micelles loaded with paliperidone palmitate

UGC-XI Plan Scheme, No. 4121, 2011-2012

1 Lakh

P.I.

Completed

2.

Transferrin receptor-targeted Vitamin E TPGS micelles for brain cancer therapy: preparation, characterization and brain distribution in rats

SERB, DST, India

(FT/SR/LS-132/2011)

2012-2015

24.82 Lakh

P.I.

Completed

3.

Polymeric nanoparticles as drug delivery systems for effective cancer therapy

DST, India SR/BY/L-41/09, 2010-2011

17.43 Lakh

P.I.

Completed

4.

Molecular biomaterials for brain targeted nano-drug delivery

DBT-CREST Awards/26/MSM/2012-13, 2013-2014

23 Lakh

P.I.

Completed

5.

TPGS-chitosan nanoparticles for cancer therapy: formulation, characterization and in-vitro fluorescence study

Institute Seed Money,

IIT-BHU

10 Lakh

P.I.

Completed

6.

Targeted theranostic nanomedicine for brain cancer therapy

R&D/BIRAC/SGAward/Phe/17-18/31

15 Lakh

P.I.

Completed

7.

 

Chitosan-folate cross-linked TPGS nanomedicine for site-specific cancer therapy

Institute Research Support,

IIT-BHU

15 Lakh

P.I.

Completed

        8.

Defining the AMR burden of antimicrobial manufacturing waste in Puducherry and Chennai

DBT, International Cooperation, Indo-UK Project

106.50 Lakh

        P.I.         Ongoing

9.

Self-assembled smart nanomedicine for targeted therapy of advanced non-small cell lung cancer

ICMR

Project ID: 2020-3011

21.27 Lakh

P.I

Ongoing

 

Total

      234 Lakh

 

 

   

4. PUBLICATIONS:

International                           :           116


National                                  :           07


Book Chapter                          :            06 


 Total                                       :           129


Cumulative impact factor: 602

       Average impact factor: 5.19                                                       .Citation per article: 48        


                        h-index: 42                                                                  RI Score: 2,103

                                                                                                          Citations: 5400

No.

PUBLICATION DETAILS

Impact

Factor

2023

                                            A. INTERNATIONAL

Singh C, Mehata AK, Viswanadh MK, Tiwari P, Saini R, Singh SK, Tilak R, Tiwari KN, Muthu MS. Chitosan film of thiolated TPGS-modified Au-Ag nanoparticles for combating multidrug-resistant bacteria. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2024 Jan 21:133287.

5.2

Singh C, Mehata AK, Muthu MS, Tiwari KN. Premna integrifolia: A Review on the Exploration of its Potential Pharmacological and Therapeutic Properties. Current Traditional Medicine. 2024;10(2):37-50.

0.6

Malik AK, Setia A, Mehata AK, Priya V, Nikitha Lakshmi Suseela M, Gokul P, Jac Fredo AR, Jain SK, Selvin J, Muthu MS. Green analytical chemistry: Experimental and chemometric methods for the detection of therapeutics using liquid chromatography in wastewater samples. Analytical Chemistry Letters. 2024 Feb 22:1-28.

2.267

Malik AK, Singh C, Tiwari P, Verma D, Mehata AK, Setia A, Mukherjee A, Muthu MS. Nanofibers of N, N, N-trimethyl chitosan capped bimetallic nanoparticles: Preparation, characterization, wound dressing and in-vivo treatment of MDR microbial infection and tracking by optical and photoacoustic imaging. International Journal of Biological Macromolecules. 2024 Feb 13:130154.

8.2

Mehata AK, Singh V, Srivastava P, Koch B, Kumar M, Muthu MS. Chitosan nanoplatform for the co-delivery of palbociclib and ultra-small magnesium nanoclusters: dual receptor targeting, therapy and imaging. Nanotheranostics. 2024 Feb 12;8(2):179-201.

Setia A, Kumari P, Mehata AK, Malik AK, Mahto SK, Muthu MS. Cetuximab decorated redox sensitive D-alpha-tocopheryl-polyethyleneglycol-1000-succinate based nanoparticles for cabazitaxel delivery: Formulation, lung targeting and enhanced anti-cancer effects. International Journal of Pharmaceutics. 2024 Feb 5:123881.

5.8

Setia A, Mehata AK, Priya V, Pradhan A, Prasanna P, Mohan S, Muthu MS. Nanoparticles for Thrombus Diagnosis and Therapy: Emerging Trends in Thrombus-theranostics. Nanotheranostics. 2024;8(2):127.

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Priya V, Samridhi, Singh N, Dash D, Muthu MS. Nattokinase Encapsulated Nanomedicine for Targeted Thrombolysis: Development, Improved in Vivo Thrombolytic Effects, and Ultrasound/Photoacoustic Imaging. Molecular Pharmaceutics. 2023 Dec 21;21(1):283-302.

4.9

Dhamija P, Mehata AK, Setia A, Priya V, Malik AK, Bonlawar J, Verma N, Badgujar P, Randhave N, Muthu MS. Nanotheranostics: Molecular Diagnostics and Nanotherapeutic Evaluation by Photoacoustic/Ultrasound Imaging in Small Animals. Molecular Pharmaceutics. 2023.

4.9

Shukla VN, Mehata AK, Setia A, Kumari P, Mahto SK, Muthu MS, Mishra SK. Rational design of surface engineered albumin nanoparticles of asiatic acid for EGFR targeted delivery to lung cancer: Formulation development and pharmacokinetics. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2023;676:132188.

5.2

Chauhan M, Singh RP, Yadav B, Shekhar S, Kumar L, Mehata AK, Jhawat V, Dutt R, Garg V, Kailashiya V, Muthu MS. Dual-targeted transferrin and AS1411 aptamer conjugated micelles for improved therapeutic efficacy and imaging of brain cancer. Colloids and Surfaces B: Biointerfaces. 2023;231:113544.

5.8

Vikas, Mehata AK, Viswanadh MK, Malik AK, Setia A, Kumari P, Mahto SK, Muthu MS. EGFR Targeted Redox Sensitive Chitosan Nanoparticles of Cabazitaxel: Dual-Targeted Cancer Therapy, Lung Distribution, and Targeting Studies by Photoacoustic and Optical Imaging. Biomacromolecules. 2023, 24, 11, 4989–5003.

6.2

Setia A, Mehata AK, Priya V, Pawde DM, Jain D, Mahto SK, Muthu MS. Current Advances in Nanotheranostics for Molecular Imaging and Therapy of Cardiovascular Disorders. Molecular Pharmaceutics. 2023;20(10):4922-41.

  4.9

Chauhan M, Singh RP, Yadav B, Shekhar S, Kumar A, Mehata AK, Nayak AK, Dutt R, Garg V, Kailashiya V, Muthu MS. Development and characterization of micelles for nucleolin-targeted co-delivery of docetaxel and upconversion nanoparticles for theranostic applications in brain cancer therapy. Journal of Drug Delivery Science and Technology. 2023 Aug 5:104808.

5

Shukla VN, Mehata AK, Setia A, Kumari P, Mahto SK, Muthu MS, Mishra SK. Rational design of surface engineered albumin nanoparticles of asiatic acid for EGFR targeted delivery to lung cancer: formulation development and pharmacokinetics. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2023 Aug 4:132188.

5.2

Shukla V, Vikas, Mehata AK, Setia Aseem, Kumar P, Mehto SK, Muthu MS. EGFR targeted albumin nanoparticles of oleanolic acid: In silico screening of nanocarrier, cytotoxicity and pharmacokinetics for lung cancer therapy. International Journal of Biomacromolecules. In press.

8.2

Mehata AK, Singh V, Vikas, Singh N, Koch B, Muthu MS. Chitosan-g-Estrone Nanoparticles of Palbociclib Vanished Hypoxic Breast Tumor After Targeted Delivery: Development and Ultrasound/Photoacoustic Imaging. ACS Applied Material Interfaces. 2023 

9.5

Revand R, Singh SK, Muthu MS. Subthreshold Doses of Inflammatory Mediators potentiate one another to Elicit Reflex Cardiorespiratory Responses in Anesthetized Rats. Cardiovascular & Hematological Agents in Medicinal Chemistry. 2023 Apr 7.

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Suseela MN, Viswanadh MK, Mehata AK, Priya V, Setia VA, Malik AK, Gokul P, Selvin J, Muthu MS. Advances in solid-phase extraction techniques: role of nanosorbents for the enrichment of antibiotics for analytical quantification. Journal of Chromatography A. 2023 Mar 21:463937.

4.1

Mehata AK, Vikas, Viswanadh MK, Muthu MS. Theranostics of metal–organic frameworks: image-guided nanomedicine for clinical translation. Nanomedicine. 2023

5.5

Mehata AK, Gupta N, Muthu MS. Exosomes as a novel nanomedicine platform for personalized triple-negative breast cancer therapy. Nanomedicine. 2023;18(6):501-4.

5.5

Setia A, Mehata AK, Malik AK, Viswanadh MK, Muthu MS. Theranostic magnetic nanoparticles: synthesis, properties, toxicity, and emerging trends for biomedical applications. Journal of Drug Delivery Science and Technology. 2023 21:104295.

5

Mehata AK, Setia A, Malik AK, Hassani R, Dailah HG, Alhazmi HA, Albarraq AA, Mohan S, Muthu MS. Vitamin E TPGS-Based Nanomedicine, Nanotheranostics, and Targeted Drug Delivery: Past, Present, and Future. Pharmaceutics. 2023 21;15(3):722.

5.4

Singh C, AK Mehata, Vikas, Malik AK, Setia A, Muthu MS. Design of novel bioadhesive chitosan film loaded with bimetallic gold-silver nanoparticles for antibiofilm and wound healing activity. Biomedical Materials. 18: 025014

4

Yadav B, Chauhan M, Shekhar S, Kumar A, Mehata AK, Nayak AK, Dutt R, Garg V, Kailashiya V, Muthu MS, Singh RP. RGD-decorated PLGA nanoparticles improved effectiveness and safety of cisplatin for lung cancer therapy. International Journal of Pharmaceutics. 2023 6:122587.

5.8

 Priya V, Singh SK, Revand R, Kumar S, Mehata AK, Susmitha P, Mahato SK, Muthu MS. GPIIb/IIIa receptor targeted rutin loaded liposomes for site-specific antithrombotic effect. Molecular Pharmaceutics. 20 (1), 663-679.

4.9

Vikas, Sahu HK, Mehata AK, Viswanadh MK, Priya V, Muthu MS. Dual-receptor-targeted nanomedicines: emerging trends and advances in lung cancer therapeutics. Nanomedicine UK 2022, 17 (19), 1375-1395

5.5

Shekhar S, Chauhan M, Sonali, Yadav B, Dutt R, Hu L, Muthu MS, Singh RP. Enhanced permeability and retention effect-focused tumor-targeted nanomedicines: latest trends, obstacles and future perspective. Nanomedicine 17 (18), 1213-1216.

5.5

Singh C, AK Mehata, Priya V, Malik AK, Setia A, Suseela M, Gokul P, Muthu MS. Bimetallic Au–Ag Nanoparticles: Advanced Nanotechnology for Tackling Antimicrobial Resistance. Molecules 2022, 27(22), 7059.

4.6

Vikas, Mehata AK, Suseela MN, Behara C, Kumar P, Mehto SK, Muthu MS. Chitosan-alginate nanoparticles of cabazitaxel: Design, dual-receptor targeting and efficacy in lung cancer model. International Journal of Biomacromolecules. 2022, 221, 874-890.

8.2

Rout SK, Priya V, Vikas, Mehata AK, Muthu MS. Abciximab coated albumin nanoparticles of rutin for improved and targeted antithrombotic effect. Journal of Drug Delivery Science and Technology 2022, 76, 103785.

5

Rout SK, Priya V, Setia A, Mehata AK, Mohan S, Albratty M, Najmi A, Meraya AM, Tambuwala MM, Muthu MS. Mitochondrial targeting Theranostic nanomedicine and molecular biomarkers for efficient cancer diagnosis and therapy. Biomedicine & Pharmacotherapy 2022, 153, 113451.

7.5

Priya V, Vikas, Mehata AK, Jain D, Singh SK, Muthu MS. Efficient delivery of abciximab using mesoporous silica nanoparticles: in-vitro assessment for targeted and improved antithrombotic activity. Colloids and Surfaces B: Biointerfaces. 2022, 112697.

5.8

Mehata AK, Suseela MN, Gokul P, Malik AK, Viswanadh MK, Singh C, Selvin J, Muthu MS. Fast and highly efficient liquid chromatographic methods for qualification and quantification of antibiotic residues from environmental waste. Microchemical Journal. 2022 May 13:107573.

4.8

Manners N, Priya V, Mehata AK, Rawat M, Mohan S, Makeen HA, Albratty M, Albarrati A, Meraya AM, Muthu MS. Theranostic Nanomedicines for the Treatment of Cardiovascular and Related Diseases: Current Strategies and Future Perspectives. Pharmaceuticals. 2022 Apr 1;15(4):441.

4.6

Singh M, Rana NK, Muthu MS, Jha A, Baul TS, Koch B. Enhanced in vitro therapeutic efficacy of triphenytin (IV) loaded vitamin E TPGS against breast cancer therapy. Materials Today Communications. 2022 Feb 11:103256.

3.8

Vikas, Viswanadh MK, Mehata AK, Sharma V, Priya V, Varshney N, Mahto SK, Muthu MS (2021). Bioadhesive chitosan nanoparticles: Dual targeting and pharmacokinetic aspects for advanced lung c10.723ancer treatment. Carbohydrate Polymers. 2021, 274: 118617.

11.2

Mehata AK, Viswanadh MK, Priya V, Vikas, Muthu MS. Harnessing immunological targets for COVID-19 immunotherapy. Future Virology. 2021 Sep;16(9):619-40.

3.1

Viswanadh MK, Agrawal N, Azad S, Jha A, Poddar S, Mahto SK, Muthu MS (2021). Novel redox-sensitive thiolated TPGS based nanoparticles for EGFR targeted lung cancer therapy. International Journal of Pharmaceutics. 602:120652.

5.8

Singh SK, Muthu MS, Revand R, Mandal MB. Intra-arterial Instillation of a Nociceptive Agent Modulates Cardiorespiratory Parameters Involving 5-HT3 and TRPV1 Receptors in Anesthetized Rats. Cardiovascular & Haematological Disorders-Drug Targets (Formerly Current Drug Targets-Cardiovascular & Hematological Disorders). 2021 Mar 1;21(1):46-54.

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Alla SK, Gangwar A, Shaw SK, Viswanadh MK, Neogi K, Muthu MS, Gupta N, Meena SS, Kollu P, Mandal RK, Prasad NK, (2021). Physical and in-vitro evaluation of pure and substituted MxCe1-xO2 (M= Co, Fe or Ti and x= 0.05) magnetic nanoparticles. Ceramics International. 47(7):8812-9.

5.2

Priya V, Viswanadh MK, Mehata AK, Jain D, Singh SK, Muthu MS. Targeted nanotherapeutics in the prophylaxis and treatment of thrombosis. Nanomedicine. 2021 Mar;16(13):1153-76.

5.5

Pawde DM, Viswanadh MK, Mehata AK, Sonkar R, Poddar S, Burande AS, Jha A, Vajanthri KY, Mahto SK, Dustakeer VA, Muthu MS., (2020).. Mannose receptor targeted bioadhesive chitosan nanoparticles of clofazimine for effective therapy of tuberculosis. Saudi Pharmaceutical Journal. 28(12):1616-25.

4.1

Sonkar R, Sonali, Jha A., Viswanadh MK, Narendra, Pawde DM, KK Patel., Singh M, Koch B, MS Muthu., (2021). Gold liposomes for brain-targeted drug delivery and bioimaging. Mater Sci Eng C Mater Biol Appl. 120, 111652.

8.32

Viswanadh, M.K., Vikas, Jha A., SK Reddy Adena, Mehata, A.K., Priya, V., K Neogi, Poddar S., Mahto S.K., Muthu, M.S., (2020). Formulation and in-vivo efficacy study of cetuximab decorated targeted bioadhesive nanomedicine for NSCLC therapy. Nanomedicine UK. 15 (24), 2345-2367

5.5

Narendra, Mehata AK, Viswanadh MK, Sonkar R, Pawde DM, Priya V, Singh M, Koch B, S Muthu M. Formulation and in vitro evaluation of upconversion nanoparticle-loaded liposomes for brain cancer. Therapeutic Delivery. 2020 Sep;11(9):557-71.

4.2

Mehata AK, Dehari D, Ayyannan SR, Muthu MS. X-ray powder diffraction spectroscopy as a robust tool in early predicting bioavailability of pharmaceutical formulation containing polymorphic drug substance. Drug Delivery Letters. 2020 Sep 1;10(3):250-4.

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Ankita SB., Jha A., Viswanadh M.K., Mehata A.K., Poddar S., Mahto S.K., Muthu M.S. (2020) EGFR targeted paclitaxel and piperine co-loaded liposomes for treatment of triple negative breast cancer. AAPS Pharm Sci Tech. USA. (2020) 21:151

3.3

Mehata, A.K., Viswanadh, M.K., Priya, V., Vikas, Muthu, M.S., (2020). Dendritic cells targeted theranostic nanomedicine: advanced cancer nanotechnology for diagnosis and therapy. Nanomedicine UK. 15(2020), 947-949s.

5.5

Jha A., Viswanadh M.K., Burande B.S., Mehata A.K., Poddar S., Yadav K., Mahto S.K., Parmar A.S., Muthu M.S. (2020) DNA biodots based targeted theranostic nanomedicine for the imaging and treatment of non-small cell lung cancer. International Journal of Biological Macromolecules. 150 (2020) 413–425.

8.2

Gangwar, A., Varghese, S.S., Meena, S.S., Viswanadh, M.K., Neogi, K., Muthu, M.S. and Prasad, N.K., Physical and in vitro evaluation of ultrafine cohenite particles for the prospective magnetic hyperthermia application. J Mater Sci: Mater Electron 31, 10772–10782 (2020).

2.8

Gangwar A, Varghese SS, Meena SS, Prajapat CL, Viswanadh MK, Neogi K, Muthu MS, Prasad NK. Physical and in-vitro evaluation of ϵ-Fe3N@ Fe3O4 nanoparticles for bioapplications. Ceramics International. 2020 Jun 1;46(8):10952-62.

5.2

Gangwar A, Kumar S, Meena SS, Sharma A, Viswanadh MK, Neogi K, Muthu MS, Prasad NK. Structural and in-vitro assessment of ZnxFe3− xC (0≤ x≤ 1) nanoparticles as magnetic biomaterials. Applied Surface Science. 2020 Apr 15;509:144891.

6.7

Vikas, Viswanadh MK, Priya V, Mehata AK, Muthu MS. What are the unexplored facts about nanomicelles formed from docetaxel clinical injection? Therapeutic Delivery. 11 (1), 801-803

4.2

Patel, K.K., Surekha, D.B., Tripathi, M., Anjum, M.M., Muthu, M.S., Tilak, R., Agrawal, A.K. and Singh, S., 2019. Antibiofilm potential of silver sulfadiazine-loaded nanoparticle formulations: a study on the effect of DNase-I on microbial biofilm and wound healing activity. Molecular pharmaceutics, 16(9), pp.3916-3925.

4.9

Mehata A.K, Bharti S, Singh P, Viswanadh M.K, Kumari L, Agrawal P, Singh S, Koch B, Muthu. M.S. (2019): Trastuzumab decorated TPGS-g-chitosan nanoparticles for targeted breast cancer therapy. Colloids and Surfaces B: Biointerfaces. 173, 366-377.

5.8

Muthu, M.S., and Sonali (2018): Stem cell therapy and nanomedicine for Alzheimier’s disease. Research and Reviews: Journal of Pharmacology and Toxicological Studies. 6(2), 14-17.

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Viswanadh, M.K., Muthu, M.S. (2018): Targeted bioadhesive nanomedicine: An effective approach for synergistic drug delivery to cancers. Nanomedicine (Lond.) 13(12), 1401–1403.

5.5

Sonali, Viswanadh M.K., Singh, R.P., Agrawal, P., Mehata, A.K., Pawde, D.M., Narendra., Sonkar, R., Muthu. M.S. (2018): Nanotheranostics: Emerging strategies for early diagnosis and therapy of brain cancer. Nanotheranostics. 2(1), 70-86.

5.28

Singh R.P., Sharma G., Sonali., Muthu M.S. (2017): Chitosan-folate decorated carbon nanotubes for site specific lung cancer delivery. Mater Sci Eng C Mater Biol Appl. 77, 446-458.

8.23

Muthu M.S., Mehata, A.K., Viswanadh, M.K. (2017): Upconversion nanotheranostics: emerging designs for integration of diagnosis and therapy. Nanomedicine 12(6), 577-580.

5.5

Agrawal, P., Singh, R.P., Sonali, Kumari, L., Mehata, A.K., Sharma, G., Singh, S., Rajesh, C.V., Koch, B., Pandey, B.L., Muthu, M.S. (2017): TPGS-chitosan crosslinked targeted nanoparticles for effective brain cancer therapy. Material Science and Engineering: C.  74, 167-176.

8.23

Agrawal, P., Sonali, Singh, R.P., Sharma, G., Koch, B., Singh, S., Mehata, A.K., Rajesh, C.V., Pandey, B.L., Muthu, M.S. (2017): Bioadhesive micelles of D-α-tocopheryl polyethylene glycol succinate 1000: synergism of chitosan and transferrin in targeted drug delivery. Colloids and Surfaces B: Biointerfaces. 152, 277-288.

5.8

Mishra, B., Upadhyay, M., Reddy Adena S.K., Vasant, B.G., Muthu M.S. (2017): Hydrogels: an introduction to a controlled drug delivery device, synthesis and application in drug delivery and tissue engineering. Austin Journal of Biomedical Engineering. 4 (1), 1037.

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Sonali, Singh, R.P., Sharma, G., Kumari, L., Koch, B., Singh, S.,Bharti, S, Rajnikanth, P.S., Pandey, B.L., Muthu, M.S. (2016): RGD-TPGS decorated theranostic liposomes for brain targeted delivery. Colloids and Surfaces B: Biointerfaces. 145, 479-491.

5.8

Vijayakumar,M.R., Kosuru,R., Singh,S.K., Prasad,C.B., Narayan,G., Muthu,M.S. (2016): Resveratrol loaded PLGA: d-α-tocopheryl polyethylene glycol 1000 succinate blend nanoparticles for brain cancer therapy. RSC Advances. 6, 74254-74268.

3.9

Vijayakumar, M.R., Vajanthri, K.Y., Balavigneshwaran, C.K., Mahto, S.K., Mishra, N., Muthu M.S. and Singh S (2016): Pharmacokinetics, biodistribution, in vitro cytotoxicity and biocompatibility of Vitamin E TPGS coated trans resveratrol liposomes. Colloids and Surfaces B: Biointerfaces. 145, 479-491.

5.8

Singh, R.P., Sharma, G., Sonali., Singh, S., Patne, S.C.U., Pandey, B.L., Koch, B., Muthu M.S. (2016): Effects of transferrin conjugated multi-walled carbon nanotubes in lung cancer delivery. Material Science and Engineering: C. C 67, 313-325.

8.23

Prakash, S., Muthu, M.S., and Singh, S (2016): Adiponectin enhancers: treatment options for obesity and diabetes. Research and Reviews: Journal of Pharmacology and Toxicological Studies. 4(1), 24-26.

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Kaklotar, D., Agrawal, P., Abdulla, A., Singh, R.P., Sonali., Mehata, A.K., Singh, S., Mishra, B., Trigunayat, A., Pandey, B.L., Muthu M.S. (2016): Transition from passive to active targeting of oral insulin nanomedicines: enhancement in bioavailability and glycaemic control in diabetes. Nanomedicine 11(11), 1465-1486.

5.5

Tay C.Y., Muthu M.S., Chia S.L., Nguyen K.T., Feng S.S., Leong D.T. (2016): Reality check for nanomaterials-mediated therapy with 3D biomimetic culture systems. Advanced Functional Materials. 26, 4046-4065.

19

Sonali, Agrawal, P., Singh R.P., Rajesh, C.V., Sanjay, S., Vijayakumar M.R., Pandey B.L., Muthu, M.S. (2016): Transferrin receptor-targeted vitamin E TPGS micelles for brain cancer therapy: preparation, characterization and brain distribution in rats. Drug Delivery. 23, 1788-1798.

6

Sonali, Singh, R.P., Singh, N., Sharma, G., Vijayakumar, M.R., Koch, B., Sanjay, S., Singh, U., Dash, D., Pandey, B.L., Muthu, M.S. (2016): Transferrin liposomes of docetaxel for brain targeted cancer applications: formulations and brain theranostics.  Drug Delivery. 23, 1261-71.

6

Singh, R.P., Sharma, G., Sonali., Singh, S., Kumar, M., Pandey, B.L., Koch, B., Muthu M.S. (2016): Vitamin E TPGS conjugated carbon nanotubes improved efficacy of docetaxel with safety for lung cancer treatment. Colloids and Surfaces B: Biointerfaces. 141:429-42.

5.8

Singh, R.P., Sharma, G., Sonali, Agrawal, P., Pandey, B.L., Koch, B., Muthu, M.S. (2016): Transferrin receptor-targeted PLA-TPGS micelles improved efficacy and safety in docetaxel delivery. International Journal of Biomacromolecules. 83:335-44.

8.2

Muthu, M.S., Agrawal, P and Singh, S (2016): Theranostic nanomedicine of gold nanoclusters: emerging platform for cancer diagnosis and therapy. Nanomedicine UK. 11:327-30.

5.5

Muthu, M.S., Sahu A.K., Sonali., Abdulla, A., Kaklotar, D., Rajesh, C.V., Sanjay, S and Pandey B.L. (2016): Solubilized delivery of paliperidone palmitate by D-alpha-tocopheryl polyethylene glycol 1000 succinate micelles for improved short-term psychotic management. Drug Delivery. 23, 230-37.

6

Kumar, D., Muthu, M.S., Pandey, B.L. (2015): Pharmacovigilance Programme in India: current status and its Indian perspectives. Research and Reviews: Journal of Pharmacology and Toxicological Studies. 3(3), 34-36.

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Kutty, R.V., Chia, S.L., Setyawati, M.I., Muthu, M.S., Feng, S.S., Leong, D.T. (2015): In vivo and ex vivo proofs of concept that cetuximab conjugated vitamin E TPGS micelles increases efficacy of delivered docetaxel against triple negative breast cancer. Biomaterials. 63, 58-69.

14

Muthu, M.S., Kutty, R.V., Luo, Z., Xie, J and Feng, S.S. (2015): Theranostic Vitamin E TPGS micelles of transferrin conjugation for targeted co-delivery of docetaxel and ultra bright gold nanoclusters. Biomaterials. 39, 3494-3501.

14

Muthu, M.S., Agrawal, P and Singh, R.P. (2014): Antipsychotic nanomedicine: a successful platform for clinical use.  Nanomedicine UK. 9 (14), 2401-2404.

5.5

Muthu, M.S., Mei, L and Feng, S.S. (2014): Nanotheranostics: advanced nanomedicine for integration of diagnosis and therapy.  Nanomedicine UK. 9 (9), 1277-1280.

5.5

Muthu, M.S, Leong D.T, Mei L and Feng, S.S. (2014): Nanotheranostics – Application and further development of nanomedicine strategies for advanced theranostics. Theranostics. 4 (6), 660-677.

12.4

Kesavan, K., Pandit, JK., Kant S and Muthu, M.S (2013): Positively charged microemulsions of dexamethasone: comparative effects of two co-surfactants on ocular drug delivery and bioavailability. Therapeutic Delivery. 4 (11), 1385-1395.

4.2

Muthu, M.S., Abdulla, A. and Pandey B.L. (2013): Major toxicities of carbon nanotubes induced by reactive oxygen species: should we worry about the effects on the lungs, liver and normal cells? Nanomedicine UK. 8 (6), 863-866.

5.5

Raju, A., Muthu, M.S. and Feng, S.S. (2013): Trastuzumab-conjugated Vitamin E TPGS liposomes for sustained and targeted delivery of docetaxel. Expert Opinion on Drug Delivery. 10 (6), 747-760.

6.6

Vijayakumar M.R., Muthu, M.S. and Singh S (2013): Co-polymers of poly (lactic acid) and D-α-tocopheryl polyethylene glycol 1000 succinate based nanomedicines: versatile multifunctional platforms for cancer diagnosis and therapy. Expert Opinion on Drug Delivery. 10 (4), 529-543.

6.6

Muthu, M.S and Feng, S.S. (2013): Theranostic liposomes for cancer diagnosis and treatment: current development and pre-clinical success.  Expert Opinion on Drug Delivery. 10 (2), 151-155.

6.6

Sahu, AK., Gautam, M.K., Deshmukh, P.T., Kushwah, L.S., Silawat, N., Akbar, Z and Muthu, M.S. (2013): Effect of embelin on lithium-induced nephrogenic diabetes insipidus in albino rats. Asian Pacific Journal of Tropical Disease. S729-S733.

Scopus Indexed

Lanjhiyana S.K., Bajpayee P., Kesavan K., Lanjhiyana S and Muthu, M.S. (2013): Chitosan-sodium alginate blended polyelectrolyte complexes as potential multiparticulate carrier system: colon targeted delivery and gamma scintigraphic imaging.  Expert Opinion on Drug Delivery. 10 (1), 5 -15.

6.6

Muthu, M.S (2012): Focus on the development of computer-aided nanomedicine design. Nanomedicine UK. 7(10), 1471-1473.

5.5

Muthu, M.S., Pandey B.L., Sahu, A.K. and Rajesh, C.V. (2012): Emerging patents for cancer-targeted nanomedicines. Pharmaceutical Patent Analyst. 1(2), 113-115.

1.3

Muthu, M.S., Kulkarni, S.A., Raju, A and Feng, S.S. (2012): Theranostic liposomes of TPGS coating for targeted co delivery of docetaxel and quantum dots. Biomaterials. 33, 3494-3501.

14

Muthu, M.S. and Wilson, B. (2012): Challenges posed by the scale-up of nanomedicines.  Nanomedicine UK. 7 (3), 307-309.

5.5

Muthu, M.S., Kulkarni S.A., Yutao L and Feng, S.S. (2012): Development of docetaxel loaded Vitamin E TPGS micelles: formulation optimization, effects on brain cancer cells and biodistribution in rats.  Nanomedicine UK. 7 (3), 353-364.

5.5

Muthu, M.S., Kulkarni, S.A., Xiong, J and Feng, S.S. (2011): Vitamin E TPGS coated liposomes enhanced cellular uptake and cytotoxicity of docetaxel in brain cancer cells. International Journal of Pharmaceutics. 421 (2), 332-340.

5.8

Muthu, M.S. and Feng, S.S. (2011): Targeted nanomedicine for the detection and treatment of circulating tumour cells.  Nanomedicine UK. 6 (4), 579-581.

5.5

Wilson, B., Samanta, MK., Muthu, M.S and Vinothapooshan, G. (2011): Design and evaluation of chitosan nanoparticles as novel drug carrier for the delivery of rivastigmine to treat alzheimer’s disease. Therapeutic Delivery. 2 (5), 599-609.

4.2

Muthu, M.S. and Feng, S.S. (2010): Nanopharmacology of liposomes developed for cancer therapy.  Nanomedicine UK. 5(7), 1017-1019.

5.5

Rawat, M.K., Jain, A., Mishra, A., Muthu, M.S and Singh, S. (2010): Effect of lipid matrix on characteristics of repaglinide loaded solid lipid nanoparticles for oral delivery. Therapeutic Delivery. 1(1), 63-73.

4.2

Singh, S., Soni, R., Rawat, M.K., Jain, A., Deshpande, S.B., Singh, S.K., and Muthu, M.S. (2010): In vitro and in vivo evaluation of buccal bioadhesive films containing salbutamol sulphate. Chem. Pharm. Bulletin. 58(3), 307-311.

1.903

Muthu, M.S. and Wilson, B. (2010): Multifunctional radionanomedicine: a novel platform for effective cancer imaging and therapy.  Nanomedicine UK. 5 (2), 169-171.

5.5

Rawat M.K., Jain A., Mishra, A., Muthu M.S., Singh, S. (2010): Development of repaglinide loaded solid lipid nanocarrier: selection of fabrication method. Current Drug Delivery. 7 (1), 44-50.

2.4

Muthu, M.S. and Feng, S.S. (2009): Pharmaceutical stability aspects of nanomedicines.  Nanomedicine UK. 4 (8), 857-860.

5.5

Muthu, M.S., Rajesh, C.V., Mishra, A., Singh, S. (2009): Stimulus responsive targeted nanomicelles for effective cancer therapy. Nanomedicine UK. 4(6), 657-667.

5.5

Muthu, M.S., Rawat, M.K., Mishra, A., Singh, S. (2009): PLGA nanoparticles formulations of risperidone: preparation and neuropharmacological evaluation. Nanomedicine (NBM). 5(3), 323-333. (Listed in Science Direct Top 25 Hottest Articles – Rank is 15)

5.4

Singh, S., Gajra, B., Muthu, M.S., Rawat, M., (2009): Enhanced transdermal delivery of ketoprofen from bioadhesive gel. Pakistan Journal of Pharmaceutical Sciences. 2(2), 193-198.

0.8

Muthu, M.S., Singh, S. (2009): Targeted nanomedicines: effective treatment modalities for cancer, AIDS and brain disorders. Nanomedicine UK. 4(1), 105-118.

5.5

Muthu, M.S and Singh, S. (2009): Poly (D, L-Lactide) nanosuspension of risperidone for parentral delivery: formulation and in vitro evaluation. Current Drug Delivery. 5(1),62-68.

2.4

Sunilson, A.J., Muthu, M.S., Mohan, M.S., Kumari, A.A.G., Thomas, J and Jeyaraj, P. (2008): Antidiabetic activity of MOMORDICA TUBEROSA (ROXB.) tuber extracts. Int J Pharmacol Biol Sci. 2(2), 41-45.

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Muthu, M.S. and Singh, S. (2008): Studies on biodegradable polymeric nanoparticles of risperidone: in-vitro and in-vivo evaluation. Nanomedicine UK. 3(3) 305-319.

5.5

Singh, S., Jain, S., Muthu, M.S., Tiwari, S., Tilek, R. (2008): Preparation and    evaluation of buccal bioadhesive films containing clotrimazole. AAPS Pharm Sci Tech. USA 9(2), 660-667.

3.3

Singh, S., Jain, S., Muthu, M.S and Tilak, R. (2008): Preparation and evaluation of buccal bioadhesive tablets containing clotrimazole. Current Drug Delivery. 5 (2), 133-141.

2.4

Singh, S., Mahendra, K., Srivastava, A.K., Garg, A. and Muthu, M.S. (2007): Effect of permeation enhancers on the iontophoretic transport of timolol maleate through rat skin.  Acta Pharmaceutica Sciencia. 49 (3), 235-252.

0.81

Singh, S., Singh, J., Muthu, M.S., Balasubramaniam, J and Mishra, B. (2007): Gastroretentive drug delivery of metoclopramide Hcl: formulation and in- vitro evaluation. Current Drug Delivery. 4(4) 269-275.

2.4

Singh, S. and Muthu, M.S. (2007): Preparation and characterization of nanoparticles containing an atypical antipsychotic agent. Nanomedicine UK. 2 (2), 233-240.

5.5

 

B. NATIONAL

 

117.

Singh, S., Singh, J., Muthu, M.S and Mishra, B (2006): Prolonged gastric retention: floating microspheres for oral controlled drug delivery. The Indian Pharmacist. 5 (53), 61-68.

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118.

Pandit, J.K., Singh, S and Muthu, M.S. (2006): Controlled release formulations in neurology practice: A review. Annals of Indian Academy of Neurology. 9 (4), 207-216.

  1.714

119.

Muthu, M.S (2009): Nanoparticles based on PLGA and its co-polymer: An overview. Asian Journal of Pharmaceutics. 3(4), 266-273.

Scopus Indexed

120.

Singh, R.P., Sonali, Mehata, A.K., Agrawal, P., Singh, S., Muthu, M.S. (2016): Carbon nanotubes: super-fabric tiny materials as lung cancer theranostics. The Pharmstudent. 27, 55-78.

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121.

Mehata, A.K., Dubey, T., Bhanukiran, K., Dehari, D., Priya, V., Muthu, M.S. (2017): Receptor targeted nanomedicine as emerging platform for brain cancer therapy: an review article. World Journal of Pharmaceutical Research. 6, 487-497.

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122.

Sonali, Singh, R.P., Viswanadh, M.K., Singh, S., Muthu, M.S. (2017): Mesoporous Silica Nanoparticles for Brain Cancer Theranostics. The Pharmstudent. 28, 36–44.

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123.

Sah, A.K., Muthu, M.S., Singh, S: (2017): Poly (D, L, Lactide-co-glycolide) (PLGA): A novel biodegradable polymer for ocular therapeutics. The Pharmstudent. 28, 59-65.

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C. BOOK CHAPTER

 

124.

Setia A, Mehata AK, Priya V, Malik AK, Muthu MS. Synthesis and processing methods of magnetic nanosystems for diagnostic tools and devices: Design strategies and physicochemical aspects. In Functionalized Magnetic Nanosystems for Diagnostic Tools and Devices 2024 Jan 1 (pp. 43-78). Elsevier.

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125.

Mehata AK, Viswanadh MK, Viswas RS. Muthu MS. Radionanotheranostics for breast cancer diagnosis and therapy: recent advances and future opportunities. 465-508. Elseiver.2022

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126.

Vikas, Mehata AK, Singh C, Malik AK, Setia A, Muthu MS. Alginate in cancer therapy. Springer Alginate Biomaterial. 267–295. 2022

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127.

Mehata AK, Dehari D, Priya V, Vikas, Muthu MS. Drug-releasing textile materials: current developments and future perspectives. 1-38, Elsevier. 2023

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128.

Mehata AK, Muthu MS. Development of supramolecules in nanomedicine. 211-239. Springer. 2023

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129.

Mehata AK, Viswanadh MK, Prasanna P, Kumar M, Muthu MS. Theranostic Applications of Upconversion Nanoparticle-Based Drug-Delivery Systems. InNanomaterial-Based Drug Delivery Systems: Therapeutic and Theranostic Applications 2023 Jun 22 (pp. 239-268). Cham: Springer International Publishing.

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130.

Vikas, Mehata AK, Singh C, Malik AK, Setia A, Muthu MS. Alginate in Cancer Therapy. InAlginate Biomaterial: Drug Delivery Strategies and Biomedical Engineering 2023 Feb 1 (pp. 267-295). Singapore: Springer Nature Singapore.

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Research Guidance

Ph.D.               : 12 - Supervisor (6 Awarded + 6 Ongoing) 

Ph. D. Scholars under supervision:

1. Abhishesh Kr Mehata (TA-SRF)

2. Ankit Malik (PMRF)

3. Gokul P. (ICMR-SRF)

4. M. Nikitha Lakshmi Suseela (DBT-SRF)

5. Aseem Setia (ICMR-JRF)

6. Vaishali (TA-JRF)

PG   24- Supervisor (21 Awarded + 3 Ongoing) 

PG Students under supervision:

1. Nidhi Verma
2. Nandini Randhave
3. Paresh Badgujar 
 

Research Associate

1. Dr. Chandrasekhar Singh

Exploratory Project     : 13

UG                                 : 21-Supervisor 
External Fellowships   : RGNF (02-Completed)

Dr. Muthu Lab's Alumini

Ph.D

1. Dr. Rahul Pratap Singh

2. Dr. Poornima Aggarwal

3. Dr. Sonali

4. Dr. Matte Kasi Viswanadh

5. Dr. Vikas

6. Dr. Vishnu Priya

M.Pharm.

  1. Abhishesh Kumar Mehata
  2. Roshan Sonkar
  3. Datta Pawde
  4. Narendra
  5. Abhishek Jha
  6. Ankita S Burande
  7. Shaikh Azad
  8. Nishi Aggarwal
  9. Amit Sanker
  10. Natasha Manner
  11. Hemendra Kumar Sahu
  12. Nilesh Khapre
  13. Piyush Dhamija
  14. Jyoti Bolnawar

IDD

1. Jitendra

Registered life time member:

  •  Pharmacy Council of India (PCI)
  • American Nano Society (U.S.A)
  • British Society for Nanomedicine (U.K.)
  • National Academy of Science (India)
  • Fellow of the Royal Society of Chemistry (FRSC), U.K.