Dr. Deepak Kumar

Assistant Professor and Ramalingaswami Fellow
Department/School/Unit Name
Department of Pharmaceutical Engineering and Technology
Phone No(s): .
Email: deepak.phe@iitbhu.ac.in
Area of Interest: Pharmaceutical and Medicinal Chemistry

Education 
B. Pharmacy, Guru Gobind Singh College of Pharmacy, Kurukshetra University, Haryana.
M. Pharmacy, ISF College of Pharmacy, Punjab Technical University, Punjab.
Ph.D., CSIR-Indian Institute of Integrative Medicine, Jammu, India with Professor (Dr.) Debaraj Mukherjee.
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Postdoctoral Training
University of Illinois (Emeritus Prof.(Dr.) Alan P Kozikowski), Chicago, USA.
University of Massachusetts Medical School (Prof. (Dr.) Stephen C Miller), Massachusetts, USA.
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Employment
Assistant Professor, Department of Pharmaceutical Engg. and Tech., IIT-BHU, Varanasi, UP.

Prestigious Awards
SERB-National Postdoctoral Fellowship
Ramalingaswami Reentry Fellowship

 

Our group is currently working on three different but complementary topics, namely Medicinal Chemistry, Fluorescence/Bioluminescence Chemistry, and Computational Chemistry. Our research lies at the interface between chemistry and biology. 

2024

1. S. Das, K. K. Verma, H. K. Indurthi, P. Saha, D. K. Sharma, Efficient Pd-catalysed Synthesis of 3-Amino-4-indolylmaleimides and 3-Amido-4-indolylmaleimides, ChemistrySelecte202304745, 9, 2024.

2. P. Kour, P. Saha, D. K. Sharma, K. Singh, DNA topoisomerases as a drug target in Leishmaniasis: Structural and mechanistic insights, International Journal of Biological Macromolecule, 128401, 256, 2024.

3. P.  Saha, S. Das, H. K. Indurthi,  R. Kumar,  A. Roy, N. P. Kalia, D. K. Sharma,. Cytochrome bd oxidase: an emerging anti-tubercular drug target, RSC Med. Chem., 2024, Advance Article

4.H. K. Indurthi, Sa. Das, P. Saha, D. K. Sharma, A Metal-Free System for Conversion of Alcohols to Amides Using tert-Butyl Nitrite, Asian Journal of Organic Chemistry, 2024  

2023

1. S. Das, H. K. Indurthi, P. Saha, D. K. Sharma, K2S2O8-Glucose-Mediated Metal-Free Oxidative Trifluoromethylation of Indoles with Langlois’ Reagent on the C2 Position, ChemistrySelecte202203939, 8, 2023.

2. D. Manhas; S. Bhatt; G. Rai; V. Kumar; S. Bharti; S. Dhiman; S. K. Jain; D. K. Sharma; P. K. Ojha; S. G. Gandhi, U. Nandi, Rottlerin renders a selective and highly potent CYP2C8 inhibition to impede EET formation for implication in cancer therapy, Chemico-Biological Interactions, 110524, 380, 2023. 

3. S. Das, P. Goswami, V. K. Verma, H. K. Indurthi, M. Kumar, B. Koch, D. K. Sharma, Rapid Access to 7-substituted Cycloalkylamino and Alkylamino Analogues of 4-methylcoumarin Reveals Surprising Emitters, Dyes and Pigments, 111407, 217, 2023.

4. P. Saha, H. K. Indurthi, S. Das, H. Diwan, D. K. Sharma, Copper Iodide Mediated Telescoped Synthesis of 3-Cyanoimidazo[1,2-a]Pyridines, Photophysical and DFT Studies, Journal of Molecular Structure, 135612, 1286, 2023.

5. P. Saha, P. Kour, R. Kumar, D. K Sharma, K2S2O8 mediated metal free oxidative coupling of alcohols with 1,2-diaminobenzenes for synthesis of benzimidazoles, photophysical and DFT studies, Journal of Molecular Structure, 136431, 1294, 2023.

6. S. Das, H. K. Indurthi, A. Kumari, D. K. Sharma, Photoinduced Synthesis of 2-Trifluoromethylated Indoles through Oxidative Trifluoromethylation Using Langlois’ Reagent in the Absence of External Photocatalyst,  Synthesis, DOI: 10.1055/s-0040-1720093, 2023

7. G. G. Naik, R. Pratap, D. Mohapatra, S. Shreya, D. K. Sharma, A. S. Parmar, A. Patra, A. N. Sahu, From phytomedicine to photomedicine: quercetin-derived carbon nanodots—synthesis, characterization and healthcare applications, Journal of Materials Science, 13744, 58, 2023.

8. P. Kour, P. Saha, S. Bhattacharya, D. Kumari, A. Debnath, A. Roy, D. K Sharma, D. Mukherjee, K. Singh, Design, synthesis, and biological evaluation of 3, 3′-diindolylmethane N-linked glycoconjugate as a leishmanial topoisomerase IB inhibitor with reduced cytotoxicity, RSC Medicinal Chemistry, 2100, 14, 2023.

9. H. K Indurthi, S. Das, P. Saha, D. K. Sharma, K2S2O8 Mediated C-3 Formylation of Imidazopyridines Using Glyoxylic Acid, Eur. J. Org. Chem. 2023, DOI: https://doi.org/10.1002/ejoc.202300829

10. D. Manhas, K. B. Mir, N. Tripathi, S. Bharti, S. Dhiman, P. Wazir, D. K Sharma, A. Goswami, U. Nandi, Rottlerin renders a selective and highly potent CYP2C8 inhibition to impede EET formation for implication in cancer therapy, Chemico-Biological Interactions 110524, 380, 2023.

11. H. K Indurthi, P. Goswami, P. Saha, B. Koch, D. K Sharma, 7-azaspiroketal as a Unique and Effective Auxochrome Moiety: Demonstration in a Fluorescent Coumarin Dyes and Application in Cell Imaging, New Journal of Chemistry, 21608-21611, 47, 2023.

12. P. Saha, R. Kumar, S. Das, T. Ansari, A. Indra, D. K Sharma, Visible light induced regioselective C-3 thiocyanation of imidazoheterocycles through naphthalimide dye based photoredox catalysis, Organic & Biomolecular Chemistry, 8471-8476, 21, 2023.

2022

1. S. Das, H. K. Indurthi, P. Asati, P. Saha, D. K.Sharma, Benzothiazole based fluorescent probes for the detection of biomolecules, physiological conditions, and ions responsible for diseases, Dyes and Pigments, 110074-110107, 199, 2022.

2. S. Das,H. K. Indurthi, P. Asati, D.K. Sharma, Small Molecule Fluorescent Probes for Sensing and Bioimaging of Nitroreductase, ChemistrySelect, e202102895, 7, 2022.

3. H. K. Indurthi,   S. Das, A. Kumari, D. K. Sharma, K2S2O8-glucose mediated oxidative coupling of alcohols with indoles for synthesis of bis(indolyl)methanes in water, New J. Chem., 13924-13930, 46, 2022.

4. A. Ranjan, D. V. Kumar, R. P.Yadav, N. Kumar, K. Jangida, P. Anand, D. K. Sharma, S. Barnawal, V. Kumar, Design, Synthesis and Evaluation of 4-Phenyl-1,2,3-Triazole Substituted Pyrimidine Derivatives as Antiproliferative and Tubulin Polymerization Inhibitors, Journal of Molecular Structure, 133592, 1267, 2022.  

5. P. Saha, S. Das, H. K. Indurthi, D. K.Sharma, Advancement in use of silicon pthalocyanine derivatives for cancer treatment, Dyes and Pigments 110608, 206, 2022.

6. D. Manhas, K. B. Mir, N. Tripathi, S. Bharti, S. Dhiman, P. Wazir, Deepak K. Sharma, A. Goswami, U. Nandi, Rottlerin promotes anti-metastatic events by ameliorating pharmacological parameters of paclitaxel: An in-vivo investigation in the orthotopic mouse model of breast cancer, Chemico-Biological Interactions, 110109, 366, 2022.

2021​

1. P. Grover, D. K Sharma, A. K. Chhalodia, D. Mukherjee, Mutasynthesis of Medicinally Significant Natural Products through the Manipulation of Gene Governing Starter Unit, Current Organic Chemistry, 1611-1625, 25, 2021.

2. HK Indurthi, R Virdi, P Koli, D Nageswara Rao, DK Sharma,"Seralite SRC-120 resin catalyzed synthesis of bis (indolyl) methanes using indoles and low/high boiling point carbonyl compounds under solvent free conditions" Synthetic Communications, 139-150, 51, 2021.

3. D. Manhas, A. Gour, N. Bhardwaj, D. K. Sharma, K. Sharma, B. Vij, S. K. Jain, G. Singh, U. Nandi, Pharmacokinetic Assessment of Rottlerin from Mallotus philippensis Using a Highly Sensitive Liquid Chromatography–Tandem Mass Spectrometry-Based Bioanalytical Method, ACS Omega 32637–32646, 6, 2021.

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2019-20​

1. Papita Koli, Reena, Rukmankesh Mehra, Deepak K. Sharma "Structure‐Activity Relationship of Indolylkojylmethane Based on Antiproliferative Activity against Breast Cancer" ChemistrySelect, 12417-12420, 5, 2020.

2. P. Koli, Reena, H K Indurthi, ''Anticancer Activity of 3,3′‐Diindolylmethane and the Molecular Mechanism Involved in Various Cancer Cell Lines''. ChemistrySelect, 11540-11548, 5, 2020.

3. D. K Sharma, S. T Adams Jr, K. L Liebmann, A. Choi, S. C Miller “Sulfonamides Are an Overlooked Class of Electron Donors in Luminogenic Luciferins and Fluorescent Dyes", Org. Lett. 1641–1644, 21, 2019.

4. D. Nayak, A. Katoch, D. Sharma, M.M. Faheem, S. Chakraborty, P. K. Sahu, N. A. Chikan, H. Amin, A. P. Gupta, S. G. Gandhi, D. Mukherjee, A. Goswami. "Indolylkojylmethane analogue IKM5 potentially inhibits invasion of breast cancer cells via attenuation of GRP78" Breast Cancer Research and Treatment, 307-323, 177, 2019.

5. D. K. Sharma, A. Magotra, A. Gour, A. K. Dash, G. Singh, D. Mukherjee, U. Nandi, " Pharmacokinetic evaluation of medicinally important synthetic N,N′ diindolylmethane glucoside: Improved synthesis and metabolic stability” Bioorg. Med. Chem. Lett. 1007-1011, 29, 2019. 

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2017-18

1. A. Katoch, S. Suklabaidya, S. Chakraborty, D. Nayak, R. U. Rasool, D. Sharma, D. Mukherjee, M. M. Faheem, A. Kumar, P. R. Sharma, S. Senapati, L. D. Kumar, A. Goswami "Dual Role of Par-4 in abrogation of EMT and switching on Mesenchymal to Epithelial Transition (MET) in metastatic pancreatic cancer cells". Molecular Carcinogenesis, 1102-1115, 57, 2018.

2. D. K Sharma, S. T Adams Jr, K. L Liebmann, S. C Miller, "Rapid Access to a Broad Range of 6′-Substituted Firefly Luciferin Analogues Reveals Surprising Emitters and Inhibitors.", Org. Lett. 5836–5839, 19, 2017.

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2014-16

1. D. K. Sharma, S Jaglan, D Mukherjee, "Isolation and conversion of Penicillic acid to 6-iodo-α-pyran-2, 5-dione: A key intermediate for the synthesis of Pectinolide F" Synthetic Communications, 902-908, 46, 2016.

2. D. K. Sharma, V. S. Rajput, S. Singh, R. Sharma, I. A. Khan, D. Mukherjee, "Ligand Free Palladium Catalyzed Synthesis of 3-Aryl/heteroaryl-4-Indolylmaleimide and its Antimicrobial Activity." Chemistry SELECT, 1954-1958, 1, 2016. 

3. D. Nayak, H. Amin, B. Rah, R. ur Rasool, D. K. Sharma, A. P. Gupta, M. Kushwaha, D. Mukherjee, A. Goswami., "A therapeutically relevant 3,3'-diindolylmethane derivative NGD16 attenuates angiogenesis by targeting glucose regulated protein, 78 kDa (GRP78)."Chem. Biol. Interact., 58-67, 232, 2015. 

4. D. K. Sharma, J.Pandey,A. K. Tamrakar,D. Mukherjee, “Synthesis of heteroaryl/arylkojic acid conjugates as stimulators of glucose uptake by GLUT4 translocation” Eur. J. Med. Chem. 727-736, 85, 2014.

5. D. K. Sharma, B. Singh,D. Mukherjee,“Aldol reaction of kojic acid using alumina supported base catalyst and enzymatic resolution of the aldol adduct by CALB” Tetrahedron lett. 5846–5850, 55, 2014.

6. M. Lambu, A. Hussain, D. K. Sharma, S. K. yousuf, B. Singh, A. K. Tripati, D. Mukherjee, “Synthesis of C-spiro-glycoconjugates from sugar lactones via zinc mediated Barbier reaction” RSC Adv., 11023-11028, 4, 2014.

7. D. K. Sharma, A. K. Tripathi, R. Sharma, R. Chib, R. ur Rasool, A. Hussain, B. Singh, A. Goswami, I. A. Khan, D. Mukherjee, “A new class of bactericidal agents against S. aureus, MRSA and VRE derived from bisindolylmethane” Med. Chem. Res., 1643-1653,23, 2014. 

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2011-2013

1. A. Hussain, S. K. Yousuf, D. K. Sharma, M.Lambu, B. Singh, D. Mukherjee,“Design and synthesis of carbohydrate based medium sized sulphur containing benzannulated macrocycles; Applications of Sonogashira and Heck coupling” Tetrahedron, 5517-5524,69, 2013.

2. M. Lambu, S. Kumar, S. K. Yousuf, D. K. Sharma, A. Hussain, A. Kumar, F. Malik, D. Mukherjee, “Medicinal chemistry of dihydropyran based medium ring macrolides related to aspergillides: selective inhibition of PI3K-alpha” J. Med. Chem., 6122–6135, 56, 2013. 

3. D. K. Sharma, M. Lambu, T. Sidiq, A. Khajuria, A. K. Tripathi, S. Khalid Yousuf, D.Mukherjee, "Ammonium chloride mediated synthesis of alkyl glycosides and evaluationof their immunomodulatory activity" RSC Adv., 11450-11455, 3, 2013.

4. D. K. Sharma, A. Hussain, M. Lambu, S. K. Yousuf, S. Maity, B. Singh, D. Mukherjee,“Fe/Al pillard clay catalyzed solvent-free synthesis of bisindolylmethanes using diverslysubstituted indoles and carbonyl compounds” RSC Adv., 2211-2215, 3, 2013.

5. A. Hussain, D. K. Sharma, A. K. Tripathi, B. Singh, D. Mukherjee, “Synthesis of carbohydrate fused chiral macrocyclic benzolactones through Sonogashira reaction” RSC Adv., 19899-19904, 3, 2013.

6. D. K. Sharma, B. Rah, M. Lambu, A. Hussain, S.K. Yousuf, G. jamwal, Z. Ahmed, N. Chanauria, A. Nargotra, A. K. Tripathi, B. Singh, A. Goswami, D. Mukherjee, “Design and synthesis of novel N, N’-glycoside derivatives of 3,3’-diindolylmethanes as potential antiproliferative agents” Med. Chem. Comm. 1082-1091, 3, 2012.

7. A. Hussain, S. K. Yousuf, D. K. Sharma, M. Lambu, A. K. Tripathi, B. Singh, S.Maiety, D. Mukherjee, “Synthesis of benzannulated chiral macrocycles embeddedin acarbohydrate template by intramolecular base free Sonogashira reaction on alumina support" Adv. Synt. And Catal., 1933–1940, 354, 2012. 

8. S. K. Yousuf, A. Hussain, D. K. Sharma, A. H. Wani, B. Singh, S. C. Taneja, D. Mukherjee, “Stereoselective conversion of dihydropyran, dihydrofuran and glycals to 1-azido-2-halo derivatives using NIS/NBS -TMSN3 combination”J. Carbohydrate Chem., 61-74, 30, 2011. 

Book Chapters
1. Deepak Kumar, S. K.Yousuf, D. Mukherjee. “Mutasynthesis of medicinally importantnatural products through manipulation of gene governing starter unit” Nat. Prod. Med.Chem. (Research Signpost) 368-391, 2010.
2.
Samarpita Das, Pulkit Asati, Harish K. Indurthi, Ashutosh Kumar Dash and Deepak K. Sharma, Recent Trends in synthesis of chromene Syntheses, Benthem Science, p: 17-42 (26) DOI: 10.2174/9789815124330123010004

 
Patents
Indolylkojylmethane analogues, process of preparation thereof, and use as inhibitor of cancer cell invasion and metastasis.Date of Grant 27/06/2017, D. Mukherjee, A. Goswami, D. Sharma, D. Nayak, S. K. Jain (WO 2019/003237, PCT/IN2018/050060), Country: IN, US, CN, CA, AU, EP


Conferences
1. National Conferences on Natural Sciences-Exploration Through Innovations, May 27-28, 2022, Maharaja Agrasen University, Solan (HP).

2. Bioluminescence based monitoring of tumor progression and treatment by apoptotic pathway, DBT Ramalingaswami Conclave 2021-2022, Online. (28-02-2022)


Workshop
1. Resource person in workshop " Patents filing procedure for students and small scale industries", Guru Gobind Singh College of Pharmacy, Yamunanagar 17.08.2022-18.08.2022.

QIP, Short Term Lecture, Special Lecture

1. (ARPIT) - 2019 scheme of Ministry of Human Resource Development (MHRD), Government of India, IIT-BHU

2. Bioimaging: A useful tool to monitor biological events in cell. IFTM University, Moradabad, Uttar Pradesh. (22-11-2021)

3. Bioluminescence imaging-A innovative technology to monitor cancer, IIC sponsored impact lecture series, Guru Gobind SIngh College of Pharmacy, Yamunanagar, Haryana. (28-07-2022)

Ph.D.
Rohit Kumar (PhD-IIT Fellowship)
Mr Rohit Kumar completed his M. Pharm. degree from IIT-BHU in 2022. He is currently doing PhD course work.

Pallavi Saha (PhD-IIT Fellowship)
Ms Pallavi Saha completed B.Pharm from MAKAUT  (Previously known as WBUT) in 2019 and M.S. (Pharm.) degree from NIPER (Mohali) in 2021. She is currently doing research on finding novel NADH II inhibitors for treatment of tuberculosis.

Harish K Indurthi (Junior Research Fellow, DBT, CSIR SRF awarded March 2024)
Mr. Harish K Indurthi obtained his Bachelor in Pharmacy in 2017 from Acharya Nagarjuna University, Guntur, Andhra Pradesh and Masters from National Institute of Pharmaceutical Education and Research, Mohali, Punjab India in 2019.  He is currently working in DBT sponsored project on bioluminescence-based monitoring of tumor progression and treatment by apoptotic pathway.

Samarpita Das (DST-Inspire Fellowship)
Ms Samarpita Das completed B.Pharm from Gupta College of Technological Sciences affiliated to MAKAUT (Previously known as WBUT) in 2018 and M.S. (Pharm.) degree from NIPER (Mohali) in 2020. Her PhD research work is synthesis of novel analogues of diindolylmethane for anticancer activity.

M. Pharmacy
Kamal, Sourbh

M. Pharmacy Alumni
Papita Koli (2021), 
Pulkit Asati, Komal (2022) Hemlata Diwan (2023)

15. Mr Harish K Indurthi received CSIR-SRF from March 2024-26.

14. Ms Samarpita achieved Best Poster Presentation Award in CD4-2023 CONFERENCE ON DRUG DEVELOPMENT & DRUG DELIVERY 21- 22 November 2023 UNIVERSITY OF LUCKNOWLUCKNOW, INDIA.

13. Mr Rohit Kumar joined our group (January, 2023) as PhD research fellow.

12. Ms. Pritha achieved CSIR JRF fellowship (April, 2022). Congratulation Pritha.
11. Ms. Pritha Janah joined our group (February, 2022) as PhD research fellow. Welcome Pritha.
10. Ms Pallavi Saha joined our group (February, 2022) as PhD research fellow. Welcome Pallavi                                                                                      

9. Ms. Samarpita Das achieved DST-Inspire fellowship (October, 2021). Congratulation Samarpita.
8. Ms Samarpita Das joined our group (March, 2021) as PhD research fellow. Welcome Samarpita
7. Harish got admission in IIT-BHU PhD course. Congratulation Harish.
6. Harish K Indurthi has joined our group as DBT-JRF, Nov, 2020. Welcome Harish.
5. Harish K. Indurthi got selected as JRF in DBT sponsored research grant, March, 2021.
4. Papita Koli has joined our group for M. Pharm Research Project, Feb, 2020. Welcome Papita.
3. Deepak received seed grant from IIT-BHU, Jan. 2020
2. Deepak recevied prestigious Ramalingaswami research grant for 5 years, Dec. 2019.
1. Dr. Deepak K Sharma joined Assistant Professor in Department of Pharmaceutical Engg and Tech. IIT-BHU, November, 2019.

1. IIT BHU Seed Grant (2019): Rs 10 Lakhs 

2. DBT sponsored, "Bioluminescence based monitoring of tumor progression and treatment by apoptotic pathway", (2019-2024): Rs 42.50 Lakhs

3. ICMR-IIRP research Grant “Targeting cytochrome bd oxidase (cyt-bd) inhibitor for the development of rational drug combination for complete sterilization of Mycobacterium tuberculosis”. (2023-26): Rs 71.03 Lakhs

4. ICMR-IIRP research Grant "Exploiting synthetic lethality of type II NADH dehydrogenases for complete sterilization of Mycobacterium tuberculosis." (20223-26): Rs 92.4 Lakhs

5. SERB-Core Research Grant "2-Mercaptobenzothiazole amides as inhibitors of type II NADH dehydrogenase with bactericidal activity against Mycobacterium tuberculosis" Rs. 41 Lakhs

We are always interested in applications from qualified candidates having their own fellowship at postdoctoral and research associate levels.
Please send your cover letter and resume to deepak.phe@itbhu.ac.in
Part-time students and summer students are encouraged to apply.